tell your doctor if you have or have ever had kidney or liver disease or heart failure. tell your doctor if you are pregnant, plan to become pregnant, or are breast-feeding. If you become pregnant while taking allopurinol, call your doctor. you should know that allopurinol may make you drowsy.

Allopurinol is associated with a small but significant reduction in BP. This effect can be potentially exploited to aid in controlling BP in hypertensive patients with hyperuricemia.

Losartan is exceptional amongst antihypertensive drugs in possessing mild uricosuric properties and therefore has a role in treating hypertensive patients with gout. Overcoming diuretic-induced hyperuricaemia is difficult and there is need for a uricosuric diuretic.

Hyperuricemia is an abnormally high level of uric acid in the blood that can lead to gout – a painful and potentially disabling form of arthritis that has been recognized since ancient times. It has long been known that people with high levels of uric acid in the blood can also have high blood pressure.

For example, a cross-sectional study determined that each 1 mg/dL increase in serum uric acid contributes a 20% increased prevalence of hypertension in a general population not treated with hyperuricemia and hypertension [1].

The sugar fructose has also been shown to raise uric acid levels. Researcher Richard Johnson, MD, and colleagues first showed that allopurinol could lower high blood pressure by lowering uric acid levels in a small study involving hypertensive preteens and teens reported last year.

The more common side effects of allopurinol oral tablet can include:

• skin rash.
• diarrhea.
• nausea.
• changes in your liver function test results.
• gout flare-up (if you have gout)

Your doctor may recommend changing these medications if you notice more gout symptoms. Aspirin or acetylsalicylic acid raises uric acid in your blood. Even low doses of aspirin can trigger gout….Medications that can trigger gout

• chlorothiazide.
• chlorthalidone.
• hydrochlorothiazide.
• indapamide.
• metolazone.
• spironolactone.

Serum uric acid (UA) has been known to have a positive association with blood pressure (BP).

The cumulative incidence of gout was higher for participants with hypertension (p-value <0.001), (Figure 1). There was an increase in the prevalence of hypertension for both participants who developed gout and those who were free from gout.

Contraindications / Precautions Gout flares may occur after initiation of urate lowering therapy, such as allopurinol, due to changing serum uric acid concentrations resulting in mobilization of urate from tissue deposits. If a gout flare occurs during treatment, allopurinol does not need to be discontinued.

You should stop taking allopurinol immediately and contact your healthcare provider if you develop a rash. Sometimes, a rash is the first sign of dangerous reactions to allopurinol, such as Stevens-Johnson syndrome (a life-threatening skin condition), liver damage,…

Other Natural Remedies to Lower Uric Acid Levels. To help reduce uric acid levels in the blood, stick with natural remedies and supplements, such as vitamin C (500 mg to 1,500 mg), fish oil supplements with 500 mg of eicosapentaenoic acid (EPA), evening primrose oil, protease enzyme products, and capsaicin creams.

Allopurinol is a maintenance treatment for gout or high uric acid levels so it should be taken regularly even once a gout attack has resolved. Other treatments (such as NSAIDs or colchicine) are usually prescribed to be taken during an acute gout attack. Seek immediate medical advice if unexplained weight loss or itchiness develop while you are taking allopurinol. Do not drive or operate machinery if allopurinol makes you drowsy or impairs your judgment.

Common allopurinol side effects may include: drowsiness; rash; abnormal liver function tests; nausea, vomiting, diarrhea; headache; or.