Lorazepam is metabolized by the liver to inactive metabolites and is considered the benzodiazepine best tolerated by patients with advanced liver disease.

As a class, the benzodiazepines do not cause significant serum enzyme elevations and have been linked to only very rare instances of acute, symptomatic liver disease.

Other drugs that can lead to liver injury include:

• Amiodarone.
• Anabolic steroids.
• Birth control pills.
• Chlorpromazine.
• Erythromycin.
• Halothane (a type of anesthesia)
• Methyldopa.
• Isoniazid.

This case may provide information on cautious use of clonazepam. When clonazepam is used for patients with existing hyperlipidaemia and liver dysfunction, it may cause abnormal lipid profile, aggravate liver dysfunction, and lead to remarkable glucose elevation.

Suddenly stopping this medication may cause serious (possibly fatal) withdrawal, especially if you have used it for a long time or in high doses. To prevent withdrawal, your doctor may lower your dose slowly.

Lorazepam causes drowsiness, so caution should be used when combining it with other medications that cause drowsiness. These could include: Antihistamines such as diphenhydramine (Benadryl®) Narcotic pain medication such as morphine, oxycodone (OxyContin®), and hydrocodone (Vicodin® and Lortab®)

Benzodiazepines most commonly used to treat anxiety disorders are clonazepam (Rivotril)*, alprazolam (Xanax) and lorazepam (Ativan). Also used are bromazepam (Lectopam), oxazepam (Serax), chlordiazepoxide (once marketed as Librium), clorazepate (Tranxene) and diazepam (Valium).

Benzodiazepines are likely to be most effective if you take them as a one-off dose. They can also be effective as a short-term treatment for a few weeks. Doctors will usually advise that you should: avoid taking them every day.

The most prominent of anti-anxiety drugs for the purpose of immediate relief are those known as benzodiazepines; among them are alprazolam (Xanax), clonazepam (Klonopin), chlordiazepoxide (Librium), diazepam (Valium), and lorazepam (Ativan).

Anxiety is a beast, but it is possible to win the battle without medication. Sometimes, overcoming worry and nervousness is simply a matter of modifying your behavior, thoughts, and lifestyle. You can start with a drug-free approach, and then speak with a doctor if your symptoms don’t improve or worsen.

You Can Manage Your Anxiety Disorder He (or she) is constantly shouting in your ear with a never-ending prattle of your most anxious thoughts and worries. Ignoring your anxiety doesn’t make it go away; the relentless thoughts just continue.