One family member may have extra digits only on their hands, while another family member may have extra digits only on their feet. *Black means has Polydactyly, white means does not. *Dominant allele example. The life expectancy for people with polydactyly is the same as a normal person without the disorder.

Polydactyly occurs in 1 in 1,000 births in the overall population, but occurs more often in African Americans with 1 in 150 births. It’s also more common in boys than girls.

About one in 500 people in the United States are affected by polydactyly, with it affecting both males and females at almost the same rate. People of Asian and Caucasian decent are more likely to have radial polydactyly. Ulnar polydactylism is more common in people of African decent.

Fast facts about polydactyly The right hand and left foot are most commonly affected. Hands are affected more often than feet. Polydactyly is twice as common among men. It occurs in 1 in 1,000 births in the general population.

The condition has an incidence of 1 in every 500 live births. Postaxial hand polydactyly is a common isolated disorder in African black children, and autosomal dominant transmission is suspected. Postaxial polydactyly is more frequent in blacks than in whites and is more frequent in male children.

Having more than five fingers is a little more complicated because it can be a dominant or recessive trait, depending on what genes are involved. If polydactyly is caused by just a single gene that only affects the number of fingers or toes and nothing else, then it is typically a dominant trait.

Inbreeding would increase the percentage of polydactyl offspring, but there will always be a few normal-toed kittens in the litter, because of that recessive gene.

Extra fingers frequently pop up as birth defects; it’s called polydactyly, and it’s a simple genetic error. But natural selection has not gripped onto those extra fingers and made them permanent. If we did develop a true sixth finger, it would probably grow up out of our wrist bones as an extra quasi-thumb.

Nerves and muscles The little finger is nearly impossible for most people to bend independently (without also bending the ring finger), due to the nerves for each finger being intertwined.

Goliath, the Gittite, is the most well known giant in the Bible. The name of Goliath’s third son does not appear in the Bible, so we have named him Exadactylus as it was said that ‘he had on every hand six fingers, and on every foot six toes’ (Samuel 21:20-21).

The extra finger or toe can occur in isolation or can be associated with other birth defects or syndromes about 15% of the time. Polydactyly is 10 times more frequent in black versus white males and 22 times more frequent in black females than white females, according to one study comparing the Southern USA and Sweden.

Six fingers or toes: The presence of an extra sixth finger or toe, a very common congenital malformation (birth defect). This condition is called hexadactyly. The word hexadactyly literally means six digits.

Laurence-Moon syndrome (LNMS) is a genetic condition that results in a complex association of problems that affect several different body parts. People with LNMS may have difficulties with functions of the brain, eyes, ears, stomach, kidneys, hands and feet.

Greig cephalopolysyndactyly syndrome (GCPS) is a rare genetic disorder characterized by physical abnormalities affecting the fingers and toes (digits) and the head and facial (craniofacial) area.

Cornelia de Lange syndrome is characterized by slow growth before and after birth leading to short stature; intellectual disability that is usually moderate to severe; and abnormalities of bones in the arms, hands, and fingers .

CdLS is a very rare disorder that is apparent at birth (congenital). Males and females appear to be affected in equal numbers. It has been estimated that CdLS occurs in approximately one in every 10,000 live births in the United States.

To diagnose CdLS, your doctor will review your child’s medical history and perform a physical examination. Your doctor may also order genetic testing to test for the specific mutations in the five genes associated with CdLS (NIPBL, RAD21, SMC3, HDAC8, and SMC1A) and other genes of interest.

Sotos syndrome is not a life-threatening disorder and patients may have a normal life expectancy. The initial abnormalities of Sotos syndrome usually resolve as the growth rate becomes normal after the first few years of life.

The findings from the present study demonstrate a high prevalence of autistic symptomatology within the Sotos population and suggest that the majority of individuals with Sotos syndrome display clinically significant behavioural symptomatology associated with ASD.

Sotos syndrome causes overgrowth during the early years of a child’s life. Children with Sotos syndrome may have several health problems and require ongoing care. There’s no cure for this genetic disorder, but some of the symptoms can be treated.

Sotos syndrome is an autosomal dominant genetic condition.

If there is an affected member of the family, a mutation in a proband should be identified before prenatal diagnosis is performed. However, more than 95% of cases of Sotos syndrome are secondary to a de novo mutation, so this is only possible in a very small percentage of cases.

Hallermann-Streiff syndrome is a very rare condition and approximately 200 cases have been reported in the literature worldwide.

RPI deficiency According to the Journal of Molecular Medicine, Ribose-5 phosphate isomerase deficiency, or RPI Deficinecy, is the rarest disease in the world with MRI and DNA analysis providing only one case in history.

LGA is usually defined as a birth weight or sonographic estimation of fetal weight above the 90th percentile. Metabolic (environmentally induced) macrosomia is distinguished from genetic or constitutional macrosomia and is defined as the growth of a fetus beyond its genetic potential.

Genetic factors and maternal conditions such as obesity or diabetes can cause fetal macrosomia. Rarely, a baby might have a medical condition that makes him or her grow faster and larger.