Another metabolic advantage of multienzyme complexes, similarly to what happens with multifunctional enzymes, is that they allow to control coordinately the catalytic activity of the enzymes that compose them.

1 The Intermediates Are Covalently Bound Sequentially to Active Sites. Pyruvate dehydrogenase complex is a multifunctional enzyme complex which catalyzes oxidative decarboxylation of pyruvate to acetyl-CoA, NADH, and CO2.

What is the advantage to having an enzyme complex, as in pyruvate dehydrogenase complex? A. Multiple steps can be regulated at one point. next enzymatic reaction.

Multienzyme complexes allow for a tighter regulation and a more rapid and efficient response to changes in equilibrium between substrate supply and demand than would the individual enzymes.

Multienzyme complex carries out a single or a series of biochemical reactions taking place in the cells. It allows to segregate certain biochemical pathways into one pace in the cell. Examples include pyruvate dehydrogenase, fatty acid synthetase, glutamine synthetase, proteasome, rubisco.

Definition. Multienzyme complexes are stable assemblies of more than one enzyme, generally involved in sequential catalytic transformations. These are distinct from a multienzyme polypeptide, in which multiple catalytic domains are found in a single polypeptide chain.

The multienzyme complex retains the product of one reaction and transfers it to the active site of another enzyme by the movement of a flexible group. This improves catalytic efficiency by increasing the chances of contact with the next active site and by providing immunity from other reactions.

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