Ecgonine methyl ester is the O-debenzoyl analogue of cocaine. It has a role as a central nervous system depressant, a peripheral nervous system drug, an analgesic, a metabolite, an opioid analgesic and a mouse metabolite.

Benzoylecgonine (BE) and ecgonine methyl ester (EME) are supposed to be the major hydrolysis products in human plasma. BE is formed by chemical hydrolysis of the methyl ester group, and small amounts of EME are formed enzymati- cally by hydrolysis of the benzoyl ester (2,4).

Pharmacogenomics of abused drugs Once absorbed, cocaine is rapidly metabolized into inactive metabolite ecgonine methyl ester by serum butylcholinesterase. Cocaine is also spontaneously hydrolyzed into benzoylecgonine, also an inactive metabolite.

4.2 hr
Ecgonine methyl ester had an elimination halflife of 4.2 hr, compared with 5.1 hr for benzoylecgonine. These results indicate that ecgonine methyl ester accounts for most of the previously unidentified urinary metabolic products of cocaine.

coca leaves
Ecgonine (tropane derivative) is a tropane alkaloid found naturally in coca leaves. It has a close structural relation to cocaine: it is both a metabolite and a precursor, and as such, it is a controlled substance in many jurisdictions, as are some substances which can be used as precursors to ecgonine itself.

EME (2,5-diethoxy-4-methoxyamphetamine) is a lesser-known psychedelic drug. It is a diethoxy-methoxy analog of TMA-2. EME was first synthesized by Alexander Shulgin. In his book PiHKAL, both the dosage and duration are unknown. EME produces few to no effects.

Coca is any of the four cultivated plants in the family Erythroxylaceae, native to western South America.

Anhydroecgonine methyl ester, or methylecgonidine, is a metabolite of smoked crack cocaine. This cocaine analog is also used as an ingredient in the production of phenyltropanes, a class of drugs used to treat cocaine dependency.

Abstract. Biodiesel (methyl esters) is a clean alternative fuel which can be produced from many renewable resources. Palm oil like other vegetable oils can be used as feedstock for biodiesel production. It is processed through transesterification to produce palm oil methyl ester.

Once absorbed, cocaine is rapidly metabolized into inactive metabolite ecgonine methyl ester by serum butylcholinesterase. Cocaine is also spontaneously hydrolyzed into benzoylecgonine, also an inactive metabolite. Butylcholinesterase is encoded by BCHE gene (located on chromosome 3) and this enzyme is synthesized in the liver.

Anhydroecgonine methyl ester (AEME) results from cocaine pyrolysis and can be used as a marker for crack cocaine use. Depending on the biological matrix examined, the amount of parent drug (cocaine) varies. The major analytes detected in various biological matrices are summarized in Table 2.2.

The conversion of EME into cocaine was studied at length by DeJong 44,45. Various solvents and alkaline drying agents were used in his benzoylations. Sinnema et al. 9 also reported benzoylations with high yields. Resolution of cocaine’s enantiomers is accomplished through bitartrate recrystallizations.