The symptoms of B. cepacia, if any, are the same as those for any lung infection and can include fever, cough, congestion, shortness of breath, and wheezing.

Burkholderia cepacia is a plant phytogen and is known as a hardy and versatile organism. Over the past two decades it has emerged as a pathogen in the cystic fibrosis (CF) community, with devastating effects. Pulmonary colonisation can lead to an accelerated decline in lung function.

NK cells kill Burkholderia. YT cells were used as effector cells against B. cenocepacia (A) or B.

While these bugs are usually harmless to people who don’t have CF, they can settle in the lungs and be harmful for those who do. One of these is a group of bacteria called Burkholderia cepacia complex (BCC), sometimes known as B. cepacia.

It colonizes in the lungs, causing infection and inflammation that slowly deteriorates lung function. It spreads (disseminates) throughout the body causing cepacia syndrome, an illness characterized by the rapid deterioration of the lungs. If left untreated, cepacia syndrome can lead to death within weeks.

B. cepacia is a fastidious gram-negative bacillus that can be difficult to isolate, since it usually grows slowly when compared to other organisms frequently found in sputum samples from CF patients, such as P. aeruginosa.

cepacia complex. Research has shown that people with CF can get B. cepacia from others who are infected with these bacteria. The germs spread either by direct contact, such as kissing, or indirectly from touching objects with the germs, such as doorknobs.

Burkholderia cepacia is an opportunistic pathogen that has become a major threat to individuals with cystic fibrosis (CF). It has been reported that culture filtrates of clinically derived strains of B. cepacia are hemolytic.

Currently, the sole method of diagnosis for B. cepacia complex infection is the culturing of the patient’s sputum. A culture will indicate which strains of Burkholderia, if any, are present within the patient [10]. Clinical indicators of BCC infection vary.

Burkholderia cepacia complex. Burkholderia cepacia complex ( BCC ), or simply Burkholderia cepacia, is a group of catalase -producing, lactose -non fermenting, Gram-negative bacteria composed of at least 20 different species, including B. cepacia, B. multivorans, B. cenocepacia, B. vietnamiensis, B. stabilis, B. ambifaria, B. dolosa,…

B. cepacia may colonize and cause respiratory tract infections in cystic fibrosis patients. It also may cause catheter-related infections in patients on hemodialysis or cancer patients through formation of biofilms.

The effects of B. cepacia on people vary widely, ranging from no symptoms at all to serious respiratory infections, especially in patients with cystic fibrosis.