Synergistic interactions occur when the combined effect of two drugs is greater than the sum of each drug’s individual activity (Cokol et al., 2011; Kalan and Wright, 2011).

What are examples of synergism? There are various examples including: (a) Carbon tetrachloride and ethanol (ethyl alcohol) are individually toxic to the liver, but together they produce much more liver injury than the sum of their individual effects on the liver.

Abstract. Two or more drugs that individually produce overtly similar effects will sometimes display greatly enhanced effects when given in combination. When the combined effect is greater than that predicted by their individual potencies, the combination is said to be synergistic.

Synergistic interaction means that the effect of two chemicals taken together is greater than the sum of their separate effect at the same doses. An example is pesticide and fertilizer.

: mutual or reciprocal action or influence.

Drug-drug. A drug-drug reaction is when there’s an interaction between two or more prescription drugs. One example is the interaction between warfarin (Coumadin), an anticoagulant (blood thinner), and fluconazole (Diflucan), an antifungal medication.

When the combined effect of two different drugs exceeds the expected additive effect of each of the drugs administered independently, one drug is said to potentiate the other. For example diazepam may potentiate the effect of alcohol.

transitive verb. : to make effective or active or more effective or more active also : to augment the activity of (something, such as a drug) synergistically.

Synergistic effects. Definition: effects when chemical substances or biological structures interact resulting in an overall effect that is greater than the sum of individual effects of any of them.

Synergism: when the combine effect of two drugs is greater than the sum of their effects when given separately. Potentiation: when one drug does not elicit a response on its own but enhances the response to another drug.

Synergistic. Notes: Calculation equations: Y = f(x); Y = g(x). An and Bn are equivalent doses, Am and Bm are equivalent doses.

An additive effect is generally considered as the baseline effect for synergy detection methods. It is the effect that is theoretically expected from the combination of multiple drugs when synergy is not present.

An interaction between two or more drugs that causes the total effect of the drugs to be greater than the sum of the individual effects of each drug. A synergistic effect can be beneficial or harmful.

When two drugs are used together, their effects can be additive (the result is what you expect when you add together the effect of each drug taken independently), synergistic (combining the drugs leads to a larger effect than expected), or antagonistic (combining the drugs leads to a smaller effect than expected).

pharmacokinetic – defined as an alteration in the absorption, distribution, metabolism or excretion of one drug by another. This is the most common type of drug interaction. pharmacodynamic – where the drug affects the action or effect of the other drug.

Most commonly interacting drug combination was aspirin + enalapril (30.2%). Conclusion: A higher incidence of polypharmacy and increased risk of potential DDIs in elderly people with cardiovascular disease are major therapeutic issues at Yekatit 12 hospital.