Gentamicin has a narrow therapeutic range in serum of 5 to 10 mg/l (10.5 to 20.9 µmol/l) for peak levels and 1 to 2 mg/l (2.1 to 4.2 µmol/l) for trough levels.

Gentamicin toxicity is the most common single known cause of bilateral vestibulopathy. In our own practice, Gentamicin causes about 1/3 of all bilateral cases. The literature suggests that Gentamicin is the cause of between 15-50% of all cases.

Rapid, direct intravenous administration may give rise, initially, to potentially neurotoxic concentrations and it is essential that the prescribed dose is administered over the recommended period of time.

Nausea, vomiting, stomach upset, or loss of appetite may occur. Pain/irritation/redness at the injection site may rarely occur. If any of these effects persist or worsen, tell your doctor or pharmacist promptly.

Gentamicin can harm your kidneys, and may also cause nerve damage or hearing loss, especially if you have kidney disease or use certain other medicines. Tell your doctor about all your medical conditions and all the medicines you are using.

Gentamicin is a broad spectrum aminoglycoside antibiotic that is most effective against aerobic gram-negative rods. Gentamicin is also used in combination with other antibiotics to treat infections caused by gram positive organisms such as Staphylococcus aureus and certain species of streptococci.

Your doctor will check your progress closely while you or your child are receiving gentamicin. This will allow your doctor to see if the medicine is working properly and to decide if you or your child should continue to receive it. Blood, urine, hearing, and nerve tests may be needed to check for unwanted effects.

Descriptions. Gentamicin injection is used to treat serious bacterial infections in many different parts of the body. Gentamicin belongs to the class of medicines known as aminoglycoside antibiotics. It works by killing bacteria or preventing their growth.

Cure rates of 62% to 98% were reported with gentamicin treatment. The relative risk of cure was comparable between gentamicin and comparator antibiotics.

The study revealed that gentamicin, in combination with azithromycin, had a lower cure rate (91%) than ceftriaxone in combination with azithromycin (98%). For those administered gentamicin, clearance was better for those with a genital infection (94%), compared with pharyngeal (80%) and rectal (90%) gonorrhoea.

The aminoglycoside class of antibiotics consists of many different agents. In the United States, gentamicin, tobramycin, amikacin, plazomicin, streptomycin, neomycin, and paromomycin are approved by the US Food and Drug Administration (FDA) and are available for clinical use.

Tetracyclines (e.g. doxycycline), quinolones (e.g. ciprofloxacin), macrolides (e.g. clarithromycin), aminoglycosides (e.g. gentamicin) and glycopeptides (e.g. vancomycin) are all unrelated to penicillins and are safe to use in the penicillin allergic patient.

Aminoglycosides such as gentamicin cannot be administered orally for treatment of systemic infection because they are not absorbed from the intact gastrointestinal tract [294].

Gentamicin is causing cytotoxicity in the cells where it accumulates. In kidney, those are usually epithelial cells of proximal tubules (Verpooten et al., 1989[91]) while cells of distal tubules and collecting ducts are significantly less affected by cytotoxic effects (Fujiwara et al., 2009[24]).

How should I take gentamicin? Follow all directions on your prescription label. Do not use this medicine in larger or smaller amounts or for longer than recommended. Gentamicin is usually given for 7 to 10 days.

fever, blisters or ulcers in your mouth, red or swollen gums, trouble swallowing; kidney problems–little or no urinating; painful or difficult urination; swelling in your feet or ankles; feeling tired or short of breath; signs of an electrolyte imbalance–confusion, weakness, bone pain, increased urination; or.

Your eye should start to feel better within a few days. Even when your eye appears normal again, there may still be some germs present. It is important to continue to use gentamicin for a further 48 hours once your eye appears normal. This will help to make sure that all the germs (bacteria) have been killed.

Gentamycin or Gentamicin sulphate is a strong antibiotic that is given intravenously (IV) to help treat bacterial infections. However, if the dose or level of medication in the body is not properly monitored, it could lead to damage to the inner ears, loss of hearing, or deafness.

Ototoxicity is irreversible and may result in cochlear damage, vestibular damage or both. Incidence of cochlear and vestibular toxicity is low in children and neonates. There is no significant difference in the incidence of ototoxicity between once daily dosing and multiple doses per day.

What Are the Signs & Symptoms of Ototoxicity?

• no problems.
• minimal hearing loss but not notice a problem.
• “ringing in the ears” (tinnitus).
• major problems with balance.
• hearing problems, usually in both ears (called bilateral hearing loss).
• profound hearing loss (deafness)