The pancreatic lipase (also referred to as pancreatic triacylglycerol lipase) is the fat-splitting enzyme secreted by the pancreas. It hydrolyzes triacylglycerol (triglyceride) to produce simpler glyceride unit and a fatty acid anion.

Lipase is an enzyme the body uses to break down fats in food so they can be absorbed in the intestines. Lipase is produced in the pancreas, mouth, and stomach.

Lipases, secreted by pancreatic acinar cells, complete fat digestion in the proximal small intestine. Of the known pancreatic lipases, pancreatic triglyceride lipase (PTL), the archetype of the lipase family, is clearly essential for the efficient digestion of dietary triglycerides.

Lipase enzymes break down fat into fatty acids and glycerol. Digestion of fat in the small intestine is helped by bile, made in the liver. Bile breaks the fat into small droplets that are easier for the lipase enzymes to work on.

Lipases: Break down fat into three fatty acids plus a glycerol molecule….Here are 12 foods that contain natural digestive enzymes.

• Pineapple. Share on Pinterest.
• Papaya.
• Mango.
• Honey.
• Bananas.
• Avocados.
• Kefir.
• Sauerkraut.

Pancreatic lipase is secreted in an active form, but its activity is enhanced by bile salts. Bile salts enhance the efficiency of lipolysis by increasing the surface area of oil-water interfaces at which water-soluble lipase is effective. Calcium may be required for activation of lipase (Janowitz and Banks, 1976).

Activated lipase was successfully inactivated in a water suspension without an oil-water interface, and the inactivated lipase could be reactivated. We demonstrated that the oil (hydrocarbon)-water interface induced reversible activation to lipase for interesterification.

It can be concluded that lipase activity can be enhanced by agitation and alkaline side of pH or reduced by heating, pasteurizing, boiling, cooling, addition of certain chemical and the acidic side of pH.

Lipase levels may also be increased with pancreatic duct obstruction, pancreatic cancer, and other pancreatic diseases, as well as with gallbladder inflammation or kidney disease. A low level of lipase in the blood may indicate permanent damage to the lipase-producing cells in the pancreas.

A low level of lipase may mean there is damage to cells in the pancreas that make lipase. This happens in certain chronic diseases such as cystic fibrosis….What do the results mean?

• Pancreatitis.
• A blockage in the pancreas.
• Kidney disease.
• Peptic ulcer.
• A problem with your gall bladder.

Low levels of lipase can mean that your pancreas is not functioning well and is struggling to produce digestive enzymes. Some conditions that can increase lipase can sometimes also decrease this enzyme.

If you don’t have enough lipase, your body will have trouble absorbing fat and the important fat-soluble vitamins (A, D, E, K). Symptoms of poor fat absorption include diarrhea and fatty bowel movements. Protease. This enzyme breaks down proteins in your diet.

An enzyme is a protein that speeds up a particular biochemical reaction in the body. People use lipase as a medicine. Lipase is used for indigestion, heartburn, allergy to gluten in wheat products (celiac disease), Crohn’s disease, and cystic fibrosis.

These include:

• severe upper abdominal pain or back pain.
• fever.
• oily or fatty stools.
• loss of appetite.
• weight loss.
• nausea with or without vomiting.

The levels return to normal within 3-6 hours and the patient is usually asymptomatic with no evidence of pancreatic inflammation. In some patients, the abdominal pain persists along with other signs and symptoms like ileus, low-grade fever or leukocytosis.

The normal range for adults younger than 60 is 10 to 140 U/L. Normal results for adults ages 60 and older is 24 to 151 U/L. Higher than normal levels of lipase mean that you have a problem with your pancreas. If your blood has 3 to 10 times the normal level of lipase, then it’s likely that you have acute pancreatitis.

Other blood tests may be used to help diagnose or detect complications of acute pancreatitis. These tests may include: Complete blood count (including white blood cell count to diagnose infection) Triglycerides.