Scleroderma is an uncommon condition that results in hard, thickened areas of skin and sometimes problems with internal organs and blood vessels. Scleroderma is caused by the immune system attacking the connective tissue under the skin and around internal organs and blood vessels.

The skin is the largest and fastest growing organ of the human body. For some people, however, it can grow too fast, caused by a condition called scleroderma. Although the cause of the disease is unknown, experts say it results in an overproduction of collagen in the body. …

The outermost layer of skin which you can see is called the epidermis. It is mostly made up of cells that produce keratin (keratinocytes). These cells are gradually pushed to the surface of the skin by newer cells, where they harden and then eventually die off.

Lichenification of the skin can be very uncomfortable. The itchiness might be intense, but scratching will only make it worse. Overall, the outlook is good and the condition is often temporary. Research suggests that lichenification can be treated quickly and effectively with a topical fluticasone propionate ointment.

Leathery-Looking Skin Use a rich, moisturizing cleanser, followed by a nourishing moisturizer. Trying a smoothing scrub two to three times a week can also aid in exfoliating the dry, dead skin, thereby brightening up the complexion and improving softness, smoothness and radiance.

What does prurigo nodularis look like? A nodule of prurigo nodularis is firm to the touch. It is usually appears as a large dome-shaped, wart-like growth up to 3 cm in diameter. The lesions start as small, red, itchy papules or rounded skin bumps.

In nodular prurigo these changes look like firm very itchy bumps (nodules) on the skin’s surface. These can improve or resolve when the person stops scratching the area, although for many people this can be very difficult without proper and sometimes prolonged medical treatment.

The combination of UV-B 308-nm excimer light and bath PUVA therapy may be effective in the treatment of prurigo nodularis. Resistant nodules have been successfully treated with excimer lasers as well. UV-A1 has also been reported to benefit lichen simplex chronicus and prurigo nodularis.

Prurigo of pregnancy involves a rash that consists of papules , which are small bumps filled with fluid. Pruritic folliculitis causes papules that resemble pimples, or acne. These conditions are uncomfortable but do not pose a risk to the pregnant person or the fetus. The rash will often disappear after delivery.

The rash usually resolves spontaneously one to two months following delivery. The exact etiology of pruritic folliculitis is unknown.