Lymphocytes of the spleen, like those of the thymus and lymph nodes, also help defend the body against infections. Thus, the spleen filters blood much as the lymph nodes filter lymph.

Hassall’s corpuscles (or thymic corpuscles (bodies)) are structures found in the medulla of the human thymus, formed from eosinophilic type VI epithelial reticular cells arranged concentrically. They can be spherical or ovoid and their epithelial cells contain keratohyalin and bundles of cytoplasmic fibres.

Scientists at UT’s M. D. Anderson Cancer Center found Hassall’s corpuscles produce chemical signals that instruct dendritic cells in the thymus to induce development of regulatory T cells — critically important immune system cells that patrol the body looking for “bad” T cells that can produce autoimmune disease.

What is the function of Hassall’s corpuscles (thymic corpuscles) in the thymus? They function in the development of a type of T cell that prevents autoimmune responses.

The thymus makes white blood cells called T lymphocytes (also called T cells). These are an important part of the body’s immune system, which helps us to fight infection. The thymus produces all our T cells before we become teenagers.

the thymus aids in the production of lymphocytes, and it is the site of maturation for t cells.

The thymus gland is in the chest, between the lungs and behind the breastbone (sternum). It is just in front of, and above, the heart. The thymus makes white blood cells called T lymphocytes (also called T cells). These are an important part of the body’s immune system, which helps us to fight infection.

The thymus produces all our T cells before we become teenagers. It gradually becomes less active and eventually gets smaller and is replaced by fat tissue. The thymus also produces a hormone called thymosin that helps make and develop T cells.

Hassall’s corpuscles. Micrograph of a thymic corpuscle. H&E stain. Details. Part of. Medulla of thymus. Anatomical terminology. Hassall’s corpuscles (or thymic corpuscles (bodies)) are structures found in the medulla of the human thymus, formed from eosinophilic type VI epithelial reticular cells arranged concentrically.

They are named for Arthur Hill Hassall, who discovered them in 1846. The function of Hassall’s corpuscles is currently unclear, and the absence of this structure in the murine thymus has restricted mechanistic dissection. It is known that Hassall’s corpuscles are a potent source of the cytokine TSLP.

Hassall’s corpuscles were stained with cytokeratin. Mann–Whitney test showed that there is no significant difference in the number of Hassall’s corpuscles in between the two sexes. Spearman’s correlation coefficient of age wise distribution of the number of Hassall’s corpuscles was -0.202, and the P value was found to be significant.

The function of Hassall’s corpuscles is currently unclear, and the absence of this structure in the thymus of the most murine (except for the New Zealand White Mouse strain) has previously restricted mechanistic dissection. It is known that Hassall’s corpuscles are a potent source of the cytokine TSLP.