All in all, Imodium A-D and Pepto-Bismol are both safe and effective over-the-counter treatments for diarrhea in most people. A few notable differences may affect which drug you choose. For example: Pepto-Bismol can treat several other related symptoms, such as heartburn, nausea, and indigestion.

Lomotil and Imodium are both effective drugs to treat diarrhea. Some research has shown that there is no significant difference in effectiveness between the two. However, other studies have shown that Imodium is more effective and better tolerated.

Imodium (Loperamide) Lomotil (diphenoxylate / atropine) is very effective at stopping diarrhea, but shouldn’t be used for all types of diarrhea. Treats diarrhea. One day is too many days to have diarrhea. Having Imodium (Loperamide) on hand to relieve your symptoms can be a life-saver.

Are Lomotil and Imodium the Same Thing? Lomotil (diphenoxylate and atropine) and Imodium (loperamide hydrochloride) are antidiarrheal medications used to treat diarrhea. Lomotil also contains an anticholinergic.

Loperamide is one of the best-known anti-diarrheal medicines.

Lomotil is contraindicated in pediatric patients less than 6 years of age due to the risks of severe respiratory depression and coma, possibly resulting in permanent brain damage or death (see CONTRAINDICATIONS). Lomotil has caused atropinism, particularly in pediatric patients with Down’s syndrome (see PRECAUTIONS).

An overdose of Lomotil can cause breathing problems and may result in death or permanent brain damage. Early overdose symptoms include weakness, blurred vision, slurred speech, feeling hot, fast heartbeats, slowed breathing, fainting, seizure, or coma.

Lomotil should not be used for diarrhea caused by certain bacterial infections (for example, Clostridium difficile). Taking Lomotil when you have this type of bacterial stomach infection can cause sepsis, a very serious and life-threatening infection.

Imodium’s half-life is between 9.1 and 14.4 hours. The average time it takes for the body to eliminate the drug is 10.8 hours. Blood concentration levels of Imodium are highest around five hours after someone takes it in capsule form and 2.5 hours after taking it in liquid form.

Drowsiness, dizziness, headache, tiredness, blurred vision, dry mouth, and loss of appetite may occur. If any of these effects persist or worsen, tell your doctor or pharmacist promptly.

Initial and Maximum Recommended Dosage in Patients 13 Years of Age and Older. The initial adult dosage is 2 Lomotil tablets four times daily (maximum total daily dose of 20 mg per day of diphenoxylate hydrochloride). Most patients will require this dosage until initial control of diarrhea has been achieved.

Diphenoxylate may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:

• nausea.
• vomiting.
• loss of appetite.
• headache.
• restlessness.
• tiredness.
• confusion.
• changes in mood.

Lomotil is a combination of two drugs: atropine and diphenoxylate. Together, these two medications are used as an antidiarrheal. Lomotil works by preventing spasms in the muscles of the gut by causing them to relax. 1 This drug also treats diarrhea by slowing the function of the bowel.

Lomotil (diphenoxylate and atropine) is a combination antidiarrheal medication, and an anticholinergic used to treat diarrhea.

Although diphenoxylate is chemically related to narcotics, it does not have pain- relieving (analgesic) actions like most other narcotics. In higher doses, however, like other narcotics, diphenoxylate can cause euphoria (elevation of mood) and physical dependence.