Our results suggest that the senescence arrest caused by telomere dysfunction is reversible, being maintained primarily by p53 and reversed by p53 inactivation.

n. 1. the biological process of growing old or the period during which this process occurs.

Senescence is a cellular response characterized by a stable growth arrest and other phenotypic alterations that include a proinflammatory secretome. Senescence plays roles in normal development, maintains tissue homeostasis, and limits tumor progression.

Cellular senescence can be initiated by a wide variety of stress inducing factors. These stress factors include both environmental and internal damaging events, abnormal cellular growth, oxidative stress, autophagy factors, among many other things.

This phenomenon known as replicative senescence, or Hayflick’s limit1, depends on the shortening of telomeres, which are repetitive sequences of DNA found at the end of linear chromosomes2. In cells that naturally lack telomere length-maintenance pathways, every time a cell divides telomere length decreases.

Cellular senescence is thought to contribute to age-related tissue and organ dysfunction and various chronic age-related diseases through various mechanisms. In a cell-autonomous manner, senescence acts to deplete the various pools of cycling cells in an organism, including stem and progenitor cells.

Reversing the aging process has been shown to be possible in some scientific experiments using human cells and simple organisms. But it’s still not possible to reverse ageing in humans yet, despite the hype about young blood transfusions in Silicon Valley.

Researchers at the Mayo Clinic Kogod Center on Aging have shown that regular exercise can reduce the signs of senescent cells and lessen some of the symptoms. The findings appear in the journal Aging Cell.

In contrast to apoptosis, senescent cells are stably viable and have the potential to influence neighboring cells through secreted soluble factors, which are collectively known as the senescence-associated secretory phenotype (SASP).

An option to eliminate the negative effects of chronic senescent cells is to kill them specifically, using compounds called senolytics (Figure 2), which target pathways activated in senescent cells [16]. The list of these senolytic tool compounds is extensive and continuously growing.

Senescence literally means “the process of growing old.” It’s defined as the period of gradual decline that follows the development phase in an organism’s life. So senescence in humans would start sometime in your 20s, at the peak of your physical strength, and continue for the rest of your life.

Summary: At high concentrations, reactive oxygen species – known as oxidants – are harmful to cells in all organisms and have been linked to aging.

STUDY SAYS IT’S POSSIBLE TO REVERSE AGING IN JUST A FEW WEEKS. Recently I came across a study, published in aging-us.com, that had some pretty impressive findings. In a nutshell, it stated that an eight-week period of dietary, supplement, sleep and relaxation changes could reverse DNA aging by up to two to three years.

11 ways to reduce premature skin aging

1. Protect your skin from the sun every day.
2. Apply self-tanner rather than get a tan.
3. If you smoke, stop.
4. Avoid repetitive facial expressions.
5. Eat a healthy, well-balanced diet.
6. Drink less alcohol.
7. Exercise most days of the week.
8. Cleanse your skin gently.

Beneath the surface, your body is aging too, and sleep loss can speed up the process. A study done by UCLA researchers discovered that just a single night of insufficient sleep can make an older adults’ cells age quicker.