The capsules are usually taken once a day at bedtime with or without food. You may want to take paroxetine with food to prevent stomach upset. Take paroxetine at around the same time every day.

anti-inflammatory painkillers (NSAIDs) such as aspirin, ibuprofen, diclofenac or naproxen (if you need a painkiller it’s fine to take paracetamol while you’re taking paroxetine)

Interactions between your drugs No interactions were found between paroxetine and Tylenol. This does not necessarily mean no interactions exist. Always consult your healthcare provider.

ibuprofen PARoxetine Using PARoxetine together with ibuprofen may increase the risk of bleeding. The interaction may be more likely if you are elderly or have kidney or liver disease. Talk to your doctor if you have any questions or concerns.

Increased symptoms Alcohol can make the symptoms of depression worse. It may also make Paxil less effective at treating depression. If the drug doesn’t work as well, your symptoms may come back. Because of these factors, people should avoid drinking alcohol while they take Paxil.

Results: While on paroxetine, systolic blood pressure and diastolic blood pressure were 10-15% lower (p < 0.005) during the stressor, relative to measures obtained while on placebo.

Paroxetine won’t change your personality or make you feel euphorically happy. It will simply help you feel like yourself again. Don’t expect to feel better overnight though. Some people feel worse during the first few weeks of treatment before they begin to feel better.

Sleep, energy, or appetite may show some improvement within the first 1-2 weeks. Improvement in these physical symptoms can be an important early signal that the medication is working. Depressed mood and lack of interest in activities may need up to 6-8 weeks to fully improve.

Paxil (Paroxetine) Withdrawal Timeline And Symptom Durations Symptoms peak in intensity at four to five days. For most people, withdrawal symptoms cease completely after two to three weeks. New research suggests that it can take as long as 90 days before the brain has fully adjusted to being off of Paxil.

The most common adverse events reported during long-term treatment with paroxetine were somnolence, nausea, headache, and sweating.

How long do they last? Typically, antidepressant discontinuation symptoms may persist for up to 4–6 weeks. In some cases, people stopping Paxil may have symptoms that last for up to 1 year.

Acute liver failure has been reported, but is very rare with paroxetine induced liver injury as is chronic liver injury. Persons with intolerance to paroxetine may have similar reactions to other SSRIs and careful monitoring is warranted if other such agents are used.

Paroxetine has been shown to be of similar efficacy to the tricyclic antidepressants but has lower cardiovascular toxicity in animal models and has no effects on heart rate, blood pressure or the electrocardiogram in healthy men receiving single 20-40 mg doses.

Paroxetine is the most potent inhibitor of the reuptake of serotonin of all selective serotonin reuptake inhibitors (SSRIs) and has been studied in many randomised controlled trials (RCTs).

The only antidepressants that don’t cause high blood pressure as a side effect are selective-serotonin reuptake inhibitors (SSRIs) such as sertraline, citalopram, fluoxetine, and paroxetine.