The nicotine from the gum makes its way into your system through the blood vessels that line your mouth. If you chew the gum without parking it, the nicotine will be released directly into the saliva in your mouth and you will swallow it. This may cause a stomachache, hiccups, or heartburn.

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When the nicotine unlocks the receptor, a feel-good chemical called dopamine is released, giving you a little hit or buzz.

Administration of nicotine gum leads to transitory elevations in blood pressure accompanied by a decrease in glomerular filtration rate (GFR) and effective renal plasma flow in nonsmokers but not in smokers[120].

6. Avoid eating and drinking (especially acidic beverages such as coffee, juice, or soft drinks) for 15 minutes before and during chewing of nicotine gum to make sure all the nicotine from the gum can get into your system. 7.

There was moderate quality evidence that higher dose nicotine patches were more effective than moderate dose patches, but no evidence that double dose patches were more effective. Likewise, there was moderate quality evidence that higher dose gum was more effective, but perhaps only for more dependent smokers.

Do not smoke or use any other nicotine replacement therapy (NRT) while using nicotine gum, because you run the risk of experiencing a nicotine overdose. Signs and symptoms of a nicotine overdose1 may include: Dizziness.

How Effective is Nicotine Gum? Nicotine gum is FDA-approved to help you quit smoking. Research shows that using FDA-approved cessation medicines, such as Nicorette® Gum, can double your chances of quitting successfully.

Per the Food and Drug Administration’s Center for Drug Evaluation and Research, a person must be at least 18 to purchase nicotine replacement therapies such as nicotine gum, lozenges, and patches.