SNRIs ease depression by affecting chemical messengers (neurotransmitters) used to communicate between brain cells. Like most antidepressants, SNRIs work by ultimately effecting changes in brain chemistry and communication in brain nerve cell circuitry known to regulate mood, to help relieve depression.

Excess serotonin in the synaptic cleft means over-activation of the post-synaptic receptors. The reuptake process is susceptible to drug manipulation. By blocking the action of serotonin reuptake inhibitors (SERTs), the amount of serotonin in the synaptic cleft increases.

Neurotransmitters that are not taken up by other nerves are taken up by the same nerves that released them. This process is termed “reuptake.” SSRIs work by inhibiting the reuptake of serotonin, an action which allows more serotonin to be available to be taken up by other nerves.

Low levels of epinephrine and norepinephrine can result in physical and mental symptoms, such as:

• anxiety.
• depression.
• changes in blood pressure.
• changes in heart rate.
• low blood sugar, or hypoglycemia.
• migraine headaches.
• problems sleeping.

Serotonin is sometimes called a “feel-good” chemical because it’s associated with positive feelings of well-being. Norepinephrine is related to alertness and energy. It’s believed that SNRIs help treat depression by keeping up the levels of these two chemical messengers in your brain.

After long-term exposure to caffeine, the brain increases production of adenosine, and decreases production of the stimulant norepinephrine to maintain equilibrium with the caffeine intake.

Drinking profoundly alters mood, arousal, behavior, and neuropsychological functioning. A subsequent group of researchers found that drinking increases levels of norepinephrine, the neurotransmitter responsible for arousal, which would account for heightened excitement when someone begins drinking.

It plays a role in your mood and ability to concentrate. Together with other hormones, norepinephrine helps the body respond to stress and exercise….You can boost these chemicals naturally through:

1. Exercise.
2. Sleep.
3. Small accomplishments.
4. Music.
5. Meditation.
6. Eating dopamine rich foods such as chocolate.

Read on to learn about different ways to increase serotonin naturally.

1. Food. You can’t directly get serotonin from food, but you can get tryptophan, an amino acid that’s converted to serotonin in your brain.
2. Exercise.
3. Bright light.
4. Supplements.
5. Massage.
6. Mood induction.

More norepinephrine floating around outside fat cells, rather than inside of them, promotes “browning” of WAT and can increase lipolysis or fat breakdown. In other words, removing Oct3 from white fat cells can increase thermogenesis.

The higher levels of norepinephrine in the body enhance the overall rate of fat loss by stimulating the release of fatty acids from fat cells into the bloodstream for burning as fuel (Johnson et al. 2012).

Mostly, losing weight is an internal process. You will first lose hard fat that surrounds your organs like liver, kidneys and then you will start to lose soft fat like waistline and thigh fat. The fat loss from around the organs makes you leaner and stronger.

Your body must dispose of fat deposits through a series of complicated metabolic pathways. The byproducts of fat metabolism leave your body: As water, through your skin (when you sweat) and your kidneys (when you urinate). As carbon dioxide, through your lungs (when you breathe out).