Combined hormonal contraceptives can prevent or decrease endometriosis pain by inhibiting ovulation and natural reproductive hormone cycling, as well as by encouraging the shrinking of endometrial-like tissue, promoting the death of endometrial-like tissue outside of the uterus, and impeding endometrial-like tissue …

Depo-Provera has been used to successfully treat endometriosis. The main reason for its effectiveness is that Depo-Provera can help prevent ovulation. Depo-Provera directly affects the endometrial tissue by causing it to thin out—this leads to lower amounts of menstrual bleeding—which leads to pain relief.

Estrogen-progesterone birth control pills are considered the best at treating endometriosis.

Depo-Provera prevents pregnancy by stopping ovulation (the release of an egg by your ovaries). It thickens your cervical mucus, which makes it hard for sperm to reach and fertilize an egg. It also thins your uterine lining, which makes it hard for a fertilized egg to implant, or attach, to your uterus.

Most people on the shot have some change in their periods, including bleeding more days than usual, spotting between periods, or no periods. This is most common during the first year. Other possible side effects include nausea, weight gain, headaches, sore breasts, or depression.

Depo-Provera CI should not be used as a long-term birth control method (i.e. longer than 2 years) unless other birth control methods are considered inadequate.

Women who get pregnant while using birth control may notice the following signs and symptoms:

1. a missed period.
2. implantation spotting or bleeding.
3. tenderness or other changes in the breasts.
4. fatigue.
5. nausea and food aversions.
6. backaches.
7. headaches.
8. a frequent need to urinate.

Of the women whose date of conception could be estimated, 113 of 258 (45%) became pregnant after the injection. There was no observed increase in ectopic pregnancy rate, and no fetal anomalies were reported. Although pregnancy during Depo-Provera use is rare, it does occur.

The birth control shot delivers a high dose of the hormone progestin. Progestin is a synthetic version of progesterone, which is a naturally occurring sex hormone in the body. Irregular bleeding is the most common side effect of the birth control shot. For many women, that side effect often goes away over time.