No interactions were found between Lasix and spironolactone. This does not necessarily mean no interactions exist. Always consult your healthcare provider.

LJ Ascites is most commonly treated with a diuretic, which removes the fluid from the abdomen. The most common such agent is spironolactone (Aldactone, Pfizer), with furosemide (Lasix, Hoechst) frequently used as an adjuvant. These medications lead directly to decreased fluid in the abdomen.

Spironolactone is the drug of choice in the initial treatment of ascites due to cirrhosis. The initial daily dose of 100 mg may have to be progressively increased up to 400 mg to achieve adequate natriuresis.

Treatments for ascites can help improve symptoms and reduce complications. In some patients, ascites may resolve with diuretic therapy or with TIPS or liver transplant.

Culture-negative neutrocytic ascites (probable SBP) is established when the ascitic fluid culture results are negative but the PMN count is 250 cells/µL or greater. This may happen in as many as 50% of patients with SBP and may not actually represent a distinctly different disease entity.

Furosemide only is a bad choice. Combination therapy is faster but more likely to have lab abnormalities that need to be monitored (azotemia, hyponatremia) Spironolactone first is slightly slower, but gentler in terms of side effects and works just as well as combination therapy.

Diuretic medicines, such as spironolactone and furosemide, can help get rid of fluid that has built up in the belly and other parts of the body. These medicines can help both prevent and treat problems with ascites.

No interactions were found between furosemide and spironolactone. This does not necessarily mean no interactions exist. Always consult your healthcare provider.

Onset of diuresis significantly slower in sequential spironolactone group (13 vs 9 days) Combination group = higher likelihood of significant increase in BUN and hyponatremia. Furosemide only group = required continually increasing doses to maintain diuresis, required large amounts of potassium supplementation.

Ascites usually occurs when the liver stops working properly, leading to a build up of fluid in the abdominal area. A doctor may diagnose ascites when more than 25 milliliters (mL) of fluid builds up inside the abdomen. When the liver malfunctions, fluid fills the space between the abdominal lining and the organs.

The PMN count is calculated by multiplying the white cells/mm3 by the percentage of neutrophils in the differential. In a bloody sample, which contains a high concentration of red blood cells, the PMN count must be corrected: 1 PMN is subtracted from the absolute PMN count for every 250 red cells/mm3 in the sample.

Spontaneous bacterial peritonitis is an infection of abdominal fluid, called ascites, that does not come from an obvious place within the abdomen, such as a hole in the intestines or a collection of pus. The condition typically affects people with liver disease, who often develop ascites as their disease worsens.

Ascitic fluid culture has an important role in the diagnosis and management of SBP. SBP, like its blood stream counterpart, is an infection of low microbial concentration (only one bacterium per ml of fluid).

Ascites that cannot be mobilised or early recurrence of which (that is, after therapeutic paracentesis) cannot be satisfactorily prevented by medical therapy. This includes two different subgroups.

Dietary salt restriction alone can create a negative sodium balance in 10% of patients. Sodium restriction has been associated with lower diuretic requirement, faster resolution of ascites, and shorter hospitalisation. In the past, dietary salt was often restricted to 22 or 50 mmol/day.

Ascites fluid analysis for cytology, amylase, brain natriuretic peptide (BNP) and adenosine deaminase should be considered based on pretest probability of specific diagnosis ( Quality of evidence: moderate; Recommendation: weak) 2.1.