Introduction: Although the most common causes of hyperprolactinemia are prolactinoma and iatrogenic, another possible cause is severe primary hypothyroidism, in which the increase of prolactin is a cause of pituitary stimulation by TRH, and can be presented with pituitary hyperplasia.

Primary hypothyroidism causes an elevation of TRH, which can cause an elevation of prolactin along with TSH. Prolactin levels in patients with hypothyroidism tend to be lower than those usually seen with prolactinomas (the latter are usually 150-200 ng/mL or higher).

Study results also revealed a positive correlation between low thyroid-stimulating hormone (TSH) levels and elevated serum prolactin levels (P = . 007).

Serum TSH levels were found to be positively correlated with prolactin levels in the cases (r=0.4, p=0.01).

Treatment for high prolactin levels

1. changing your diet and keeping your stress levels down.
2. stopping high-intensity workouts or activities that overwhelm you.
3. avoiding clothing that makes your chest uncomfortable.
4. avoiding activities and clothing that overstimulate your nipples.
5. taking vitamin B-6 and vitamin E supplements.

In hypothyroidism patients, TRH is the stimulant factor of rising prolactin level. A previous study suggested that perhaps estrogen caused to increase prolactin response to TRH that caused higher prolactin level in woman than men (22).

Excess prolactin can cause the production of breast milk in men and in women who are not pregnant or breastfeeding. In women, too much prolactin can also cause menstrual problems and infertility (the inability to get pregnant). In men, it can lead to lower sex drive and erectile dysfunction (ED).

Conclusion: Weight gain and elevated body weight are frequently associated with prolactinomas regardless of a mass effect on the hypothalamus or pituitary function. In this series, weight loss was recorded in 70% of prolactinomas patients and in 90% of male patients who normalized their prolactin levels.

Foods that lower prolactin levels are generally high in zinc; think shellfish, beef, turkey and beans. It’s also important to get plenty of B6, so foods like potatoes, bananas, wild salmon, chicken and spinach can help boost those vitamin levels.

Calcitriol, the hormonal form of vitamin D(3), exerts immunomodulatory effects through the vitamin D(3) receptor (VDR) and increases prolactin (PRL) expression in the pituitary and decidua.

High prolactin levels inhibit secretion of FSH, which is the hormone that triggers ovulation. So, if your prolactin levels are high, your ovulation may be suppressed. This is why women who are breastfeeding (and thus have high levels of prolactin) usually don’t become pregnant.

These results show that vitamin E treatment lowers prolactin levels in uremic hemodialysis patients. This might be due to inhibition of central prolactin secretion. Vitamin E inhibits pituitary gland hypertrophy in vitamin E-deficient rats.

Vitamin B6 is an effective prolactin inhibitor that is extremely cheap and safe.it exerts hypothalamic dopaminergic effect which causes a significant reduction in prolactin level.

Normal Results The normal values for prolactin are: Men: less than 20 ng/mL (425 µg/L) Nonpregnant women: less than 25 ng/mL (25 µg/L) Pregnant women: 80 to 400 ng/mL (80 to 400 µg/L)

Conclusion. Moderate elevated prolactin levels in association with diffuse or androgenetic hair loss can be neglected as causative for the hair loss because there is no evidence that they have an influence to the pattern, the extent or the duration of the hair loss.

Symptoms of Prolactinoma For women, this causes symptoms such as: Irregular or no menstrual periods (amenorrhea) Acne. Increase or thickening of body hair and facial hair.

In males, prolactinoma can cause: Erectile dysfunction. Decreased body and facial hair. Enlarged breasts, uncommonly.

In contrast, clinical studies in humans have indicated a correlation between high PRL levels and psychological distress. Female patients with hyperprolactinemia usually report more symptoms of anxiety and hostility than control female subjects (24).

Hirsutism is excess hair growth on the body or face. It’s caused by excess hormones called androgens. For women, the hair may grow in places where men often have a lot of hair, but women often don’t. This includes the upper lip, chin, chest, and back.